Endocrine Abstracts

Wnts are a large family of carbohydrate- and lipid-modified growth factors that mediate essential biological processes such as embryogenesis, morphogenesis and organogenesis. These proteins bind to a membrane receptor complex comprised of a frizzled (FZD) G-protein-coupled receptor and a low-density lipoprotein (LDL) receptor-related protein (LRP). The formation of this ligand-receptor complex initiates a number of signaling cascades that includes the canonical/beta-catenin pa...